Thyroid parafollicular cells in intact pigs, neonatally treated with gonadal steroids or castrated
1995
Sekulic, M. | Lovren, M. (Institute for Biological Research, Belgrade (Yugoslavia). Division of Cytology and Embryology)
The parafollicular cells (PCs) of male pigs treated with estradiol-dipropionate (EDP) and progesterone (Pr) in combination, or castrated on the first day of life and sacrificed 6 or 8 months later were investigated. Treatment with EDP + Pr led to a significant decrease in the number of PCs per unit area, volume density and volume of their nuclei as compared to intact animals (by 25, 36 and 83, respectively). Prominently dilated GER and the small number of secretory granules suggested a slower rate of secretion by PCs. Castration led to a decrease in number of PCs per unit area by 18 and an increase of volume density by 5 in 6-month pigs in comparison with intact controls. The markedly developed lamellar structure of GER with numerous attached ribosomes and many mitochondria in the cytoplasm of PCs of castrated pigs, suggested stimulation of specific protein synthesis.
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