Bovine leukocyte adhesion deficiency. A brief overview of a modern disease and its implications
1996
Gerardi, A.S.
Bovine leukocyte adhesion deficiency (BLAD) is a genetic disease of cattle affecting the hematopoietic system. In the last decade BLAD has become a disease of economic importance in the dairy industry. As such, this overview describes the chronological developments and thinking that led to the elucidation of BLAD as a distinct disease entity from previous models in canine and human populations. The economic significance and prophylaxis are briefly discussed. In addition, the beneficial aspects of the study of BLAD are addressed. There are advantages of producing a BLAD-like state in preventing transplant rejection, ischemia reperfusion injury, and other scenarios arising from the deleterious effects of the inflammatory response
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