Effect of cholesterol diet on lipoprotein profile and on pro- and antioxidative status of rat
1997
Bobek, P. (Research Inst. of Nutrition, Bratislava (Slovak Republic)) | Ozdin, L. | Hromadova, M.
The effect of cholesterol (0.3 percent) diet on cholesterol levels in serum and liver, on cholesterol distribution in lipoproteins, lipid peroxidation and on the activities of antioxidant enzymes in erythrocytes and liver was studied in male Wistar rats after 8 and 52 weeks of feeding the diet. Cholesterol diet elevated serum cholesterol levels similarly - approximately by three times - in both experimental time intervals. Cholesterolaemia increased by 50-60 percent both in control diet group and the cholesterol group within the duration of the experiment. Cholesterolaemia induced by a cholesterol diet was determined essentially by increased cholesterol content in very low density lipoproteins. The contribution of cholesterol in high-density lipoproteins decreased from the physiological values (70 percent in control group) to 28 or 19 percent, depending on the duration of the experiment, in animals fed the cholesterol diet. Cholesterol content in liver increased 20- or 40-fold, depending on the period of administration of the cholesterol diet. After 8 weeks, cholesterol diet stimulated the activities of SOD and GSH-Px, whereas GSH-Px activity was dependent on the duration of the experiment for both diets. On the contrary, cholesterol diet reduced by several times GSH-Px activity in the liver. This diet also reduced LCAT activity in plasma and HMG-CoA reductase activity in liver
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