The present status of anthelmintic resistance in domestic animals in Slovak Republic
1998
Corba, J. | Varady, M. | Praslicka, J. | Tomasovicova, O. | Konigova, A. (Slovenska Akademia Vied, Kosice (Slovak Republic). Parazitologicky Ustav)
In an experiment on sheep, goats and horses, the presence of anthelmintic-resistant gastrointestinal nematodes was studied. In a survey of larger flocks of sheep (total of 75 farms, species Merino, Tsigaya and Valaska) the benzimidazole-resistance was found on 7 farms, but in other 58 flocks the levels were close to reference values. Experimentally we confirmed the presence of levamisole and tetramisole resistance in Ostertagia spp. and Trichostrongylus spp. in domestic flocks of sheep. For the first time on a world-scale the transcontinental transfer of polyresistant isolates of gastrointestinal nematodes of Angora goats imported to Slovakia from New Zealand was observed. We confirmed that the effective doses of anthelmintics, recommended for sheep, should be at least twice as high for goats, because the pharmacokinetics and bioavailability of drugs is different in sheep and in goats. We started the survey of the anthelmintic resistance in horses and on both farms the presence of benzimidazole-resistant small strongyles was confirmed. The efficacy of recommended doses of mebendazole and fenbendazole was only 31.7 and 83.5%, respectively
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