Biologically active substances in cells of mammal ovaries
1998
Sirotkin, A. (Vyskumny Ustav Zivocisnej Vyroby, Nitra (Slovak Republic))
The aim of our work was to investigate the regulation of the secretory activity of bovine, porcine, human, rabbit and mouse ovaries. In particular, the production of oxytocin, vasopresin, prolactin-like substance, insulin-like growth factor-I, insulin-like growth factor binding protein-3, an inhibitor of oocyte maturation, leukocyte attractant, prostaglandins F2-alpha and E2, receptors to LH/hCG, aromatase, progesterone, testosterone, androstenedi one, estradiol, cAMP minus and CA2 plus or minus dependent intracellular mechanisms in the control of secretion of ovarian substances at various stages of the reproductive cycle were investigated. The secretion of the majority of these substances by bovine, percine, human, rabit and mouse ovaries was confirmed. Significant differences in basal secretion of ovarian substances between species and at different stages of reproductive cycle, as well as in the response of ovarian cells to hormonal and pharmacological treatments suggest differences in the endocrine mechanisms of sexual maturation, cyclicity and pregnancy between the species investigated. On the other hand, it was demonstrated that gonadotropins, growth hormone, prolactin LH-RH, nonapeptide and steroid hormones, prostaglandins, Ca2 plus or minus and cAMP minus dependent intracellular mechanisms are important elements in the control of ovarian secretion in all species investigated. Both synergistic and antagonistic interrelationships between these substances in the regulation of ovarian secretory activity were discovered. Furthermore, it was shown that synthetic analogues of hormones and the drugs influencing intracellular messenger systems can modulate, mimic or replace the ordinary hormonal regulators of ovarian function
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