Biochemical reactions in vitro of certain fungi to the presence of hypericin
1997
Solujic, S. (Faculty of Sciences, Kragujevac (Yugoslavia). Department of Chemistry and Biology) | Sukdolak, S. | Comic, Lj. | Krstic, Lj.
In this work, the biochemical reactions of the fungi Aspergillus niger, Penicillium verrucosum, Trichoderma viride, Trichoderma harzianum, Doratomyces stemonitis to the presence of 30 mg/ml, hypericin, added to the standard nutrient base, were investigated. Hypericin acts in two ways either as an activator of biochemical reactions or as an inhibitor, depending on the fungal species. In already prepared methylene chloride extracts of 14-day old fungi, both the number and the chemical ctructures of biodegradational products were examined in order to register the possible involvement of hypericin in fungal biochemical reactions and to determine the level of biodegradation. The rate of biodegradation and the number of biodegradational products differed from case to case, with protohypericin as a common intermediary compound. Hypericin was bactericidal to Streptococcus A, Streptococcus B, Enterococcus, Escherichia coli and P. mirabilis in the concentrations of 10 mg/ml, and 20 mg/ml.
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