The adrenal cortex in male rats after centrally applied somatostatin (SRIF-28): stereology and hormone concentrations
1998
Milosevic, V. (Institute for Biological Research "Sinisa Stankovic", Belgrade (Yugoslavia))
The effects of intracerebroventricular (i.c.v.) administration of somatostatin (SRIF-28) on zona glomerulosa, zona fasciculata and zona reticularis of the adrenal cortex and on the blood concentrations of adrenocorticotropic hormone, prolactin, growth hormone, aldosterone, cortisol, progesterone, estradiol, Na+ and K+ in male rats were studied. Each experimental animals was given three 1 microgram doses of SRIF-28 dissolved in 5 microliter saline by the i.c.v. route every second day. Controls were treated in the same way with the same volume of saline. On the basis of obtained results, it can be concluded that centrally applied SRIF-28 inhibits both the secretory activity and growth of adrenal zona glomerulosa cells but insignificantly affects zona fasciculata and zona reticularis cells.
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