Desmutagenic and bio-antimutagenic effects of the extracts from Japanese miso in Salmonella assay
1998
Yoshikawa, K. (Kinki Univ., Higashiosaka, Osaka (Japan). Faculty of Agriculture) | Oda, N. | Aryal, P. | Terashita, T. | Shishiyama, J.
Using a Salmonella/microsome assay, the antimutagenic effects of specific components of the extracts from Japanese Miso were investigated. Miso exhibited an antimutagenic activity against ethyl methanesulfonate (EMS)-induced mutagenicity. This activity was recognized in the fractions extracted with acetone and ether. The soybean-koji miso showed markedly antimutagenic effects with both ether layer (fraction 1) and water layer (fraction 2). No mutagenicity or toxicity was observed for Salmonella typhimurium TA100 using any of the extracts. To study the mechanism of the activity, the extracts of soybean-koji miso were employed further for desmutagenic test and bio-antimutagenic test. Fraction 1 extract was observed to exhibit both the desmutagenic effect and the bio-antimutagenic effect, but fraction 2 was observed to exhibit only the desmutagenic effect. It is suggested that miso is composed of multiple components with the antimutagenic activities
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