Morphology of adrenal gland and lymph organs is impaired in neurodeficient lurcher mutant mice
2002
Beranova, M. | Slipka, J. | Kocova, J. (Karlova Univ., Plzen (Czech Republic). Ustav Histologie a Embryologie) | Mandakova, P. | Sima, P. | Cervinkova, M. | Vozeh, F. | Sykora, J.
Microscopical analyses of selected immune organs (thymus, spleen, inguinal and subscapular lymph nodes) and of the adrenal gland of the neurodeficient Lurcher mutant mice and control C3H mice were performed. In the neurodeficient mice the morphology of the immune organs was impaired. The changes in the spleen, especially the increased number of megakaryocytes, lead to the hypothesis of enhanced extramedullar hemopoiesis in the neurodeficient Lurcher mutant mice. Histopathological analysis of the adrenal gland showed a hypertrophy of adrenal medulla. The three cortical zones (zona glomerularis, fasciculata and reticularis) are difficult to be distinguished. It has been supposed that structural changes of adrenal medulla could document the increased secretion of catecholamines in the neurodeficient animals. Our observations confirm the idea of the tight cooperation of neuro-endocrine-immune spucutres and contribute to its better understanding, especially in the conditions of postnatally progressing neurodeficiency.
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