Protective effects of beta-blocker carvedilol by experimentally induced solar burn in rats
2001
Necas, J. | Bartosikova, L. | Petrzelkova, J. | Kollar, P. | Kotolova, H. | Strnadova, V. | Bartosova, L. | Frana, L. (Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Farmaceuticka Fakulta) | Frana, P. | Klusakova, J. | Salplachta, J.
We studied whether carvedilol can reduce renal damage induced by solar thermal effect in 17 days long experiment. A solar emittor was used to develop solar erythema within the range of 30 % of the total body surface of narcotised experimental rats. The animals were randomly assigned to two equal groups (n = 7). The group 1 was treated with CVD at a dose of 10 mg/kg/day administered in 1 mL of saline i.p. Group 2 (placebo group) was given 1 mL of saline i.p./day. Protein and malonyldialdehyde (MDA) concentrations were determined in serum samples obtained on days 1, 8 and 17. Proteinuria and total protein loss per day were measured in urine samples daily. Serum protein levels of the two experimental groups did not differ significantly during the period under study. Serum MDA of the placebo group surpassed significantly that of the treated group on days 8 and 17. Protein concentrations in urine of CVD-treated animals were lower than those of the placebo group during the entire experimental period except for days 4 and 5. Total protein loss per day in urine showed similar differences between both groups. Carvedilol apparently protects renal function in experimentally induced thermal injury by increased renal blood flow and by its antioxidant effect.
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