Binding capacity of rat liver glucocorticoid receptor in different periods after single neonatal benzpyrene treatment (imprinting)
2001
Csaba, G. | Inczefi-Gonda, A.
Newborn rats of both sexes were treated (imprinted) with benzpyrene. Two hours, 2 days, 1, 2, 3 weeks, 1 month and 2 months after imprinting the liver glucocorticoid receptors were studied for binding of dexamethasone. Two-hour and 2-day values were not appreciable. One week after treatment the receptor's affinity was extremely low both in control and treated animals. Two weeks after imprinting a significant difference in density (lower) and affinity (higher) was observed between the male treated and control animals. This means that for the development of perinatal imprinting effect a long time is needed, and the effect is manifested after a period of lability.
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