Direct effect of bile on colonic mucosa in alimentary induced hyperlipidemy in rats
2001
Sipos, P. | Hagymasi, K. | Lugasi, A. | Feher, E. | Feher, E. | Blazovics, A.
An experimental surgical model was developed in rats after a short term alimentary induced hyperlipidemy to study the direct effect of bile on the colonic mucosa, with regard to the cancerogenic properties of lipid rich diet. The purpose of this study was to light on the role of fatty acid alteration and lipid peroxidation processes of bile in the epithelial cell damage. Animals were fed with normal (group A) and fat rich diet (group B) for 10 days and then bile samples were collected by the cannulation of the common bile duct in deep anaesthesia.
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