Cellulolytic bacteria in human gut and irritable bowel syndrome
2002
Kopecny, J. | Simunek, J. (Akademie Ved, Prague (Czech Republic). Ustav Zivocisne Fyziologie a Genetiky)
The aim of the present study was to investigate the composition and metabolic activities of faecal flora in patients with irritable bowel syndrome (IBS). All experiments were designed for three groups of stool donors: healthy individuals, IBS patients before and after treatment by prebiotic preparation Hylak Tropfen Forte (HTF). Concentrations of acetate, propionate and total faecal short chain fatty acids were low in IBF patients but increased after treatment with HTF. On the contrary, butyrate concentration which was high in IBS patients decreased after the treatment as well as numbers of facultative anaerobes and sulphate reducing bacteria. The proportion of cellulolytic bacteria increased significantly to a similar level as in healthy persons. Starch degradation of faecal bacteria was significantly depressed, while pectin degradation in vitro followed a similar pattern. No degradation of cellulose was found. Bacterial degradation of these polysaccharides increased after treatment but not to the levels of the control group.
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