Temporal Enzymatic Activity of Lymphocyte-Specific Deubiquitinating Enzymes

Lee, J.H.; Kim, Y.S.

Temporal Enzymatic Activity of Lymphocyte-Specific Deubiquitinating Enzymes

2001

Lee, J.H. | Kim, Y.S. (Pochon CHA University, Seoul, Korea Republic)

Ubiquitin-mediated proteolysis is a rapid, highly specific molecular mechanism for regulating biological processes. This proteolysis destines proteins conjugated with ubiquitin, a small polypeptide, for either degradation by the proteasome or removal of the ubiquitin by a family of deubiquitinating enzymes, thereby stabilizing the protein from degradation. Mouse DUB-1 and DUB-2 recently have been isolated and cloned.

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