Screening of Antimicrobial Activity from the Marine-Derived Fungus
2003
XiFeng, Li. | Yong, Li. | Son, B.W. (Pukyong National University, Busan, Republic of Korea) | Choi, H.D. (Dongeui University, Busan, Republic of Korea)
Acetone extracts of 301 strains of marine-derived fungus were tested for antimicrobial activity against three strains of bacteria. The bacteria consisted of three pathogens, Staphylococcus aureus, Methicillin-resistant S. aureus, and multidrugresistant S. aureus. The acetone extracts of 10 strains (MFA117, MFA130, MFA134, MFA206, MFA217, MFA268, MFA277, MFA291, MFA292, MFA301) showed strong activity, inhibiting 100% of the bacterial growth. These antimicrobial active stains were cultured in SWS midium on a 1L scale and the resulting broth and mycelium were extracted to afford mycelium extract (000M) and broth extract (000B), respectively. Antimicrobial activity for all extracts has been tested. As the results, the mycelium extract of one strain (217M) and the broth extracts of 9 strains (117B, 130B, 134B, 206B, 268B, 277B, 291B, 292B, 301B) exhibited relatively high levels of activity at minimal inhibitory concentration (MIC) values of 500-125 §¶/mL range. Among them, the extracts, 277B, 291B, 292B and 301B showed the most significant antimicrobial activity with IC50 values of 125 §¶/mL.
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