Plasma free amino acids and protein metabolic products as biochemical biomarkers in chicks after cadmium exposure
2003
Vasiljeva, S. (University of Latvia, Salaspils (Latvia). Inst. of Biology) | Basova, N. (University of Latvia, Salaspils (Latvia). Inst. of Biology) | Smirnova, G. (University of Latvia, Salaspils (Latvia). Inst. of Biology) | Berzina, N. (University of Latvia, Salaspils (Latvia). Inst. of Biology)
The protein assimilation in poultry dependson numerous factors including the ecological pollution. High toxicity of cadmium (Cd) can cause different metabolic damages in an organism even when rather mild doses are exposed to humans and animals. The experimental Cd-induced protein metabolism changes in chicks were investigated. The 1-35-day old Lohmann brown cockerels were per os administered Cd (1mg/kg body mass as CdCl2) and from the 1st day fed with a diet both with and without supplementation of Zn (500mg/kg as ZnCl2). The disturbance of protein metabolism established at the different stages under Cd influence in chicks: the decrease of plasma free amino acid pool and some individual amino acid concentration, blood hemoglobine and blood serum total protein level. The opposite Cd effect was observed in connection with the final metabolic products: the increase of creatine and uric acid concentration in chickens' blood serum was noted. The observed biochemical biomarkers in chicks were close to the control group data when the diet prior has been supplemented by Zn. the protein metabolic indices normalization here evidences the preventive action of Zn against Cd toxicity.
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