Neurotoxicological effects of steroidal compounds in changes of cholesterol level on albino rat brain
2002
Ilyas, M. | Khan, E.H. | Shafi, S. (Aligarh Muslim Univ. (India). Dept. of Chemistry) | Rizvi, S.J.
Changes in the level-of cholesterol in albino rat brain (cerebrum hemisphere, cerebellum and brain stem) were evaluated following the administration of four steroidal derivatives as 3- beta-Acetoxy-5-bromo 6- beta succinimido. 5 alpha-cholestane A(I), 3 beta-chloro-5-bromo 6 beta- amino-5 alpha- cholestane B(II), 3 beta-Acetoxy-6-phthalimid cholest-5-ene C(III) and 6-nitro cholest 5-eno (3 alpha-4 alpha-dl oxazolidin-2-one D(IV). Experiments were carried out on four groups of six male albino rats weighing 200 plus minus 20 gm. Control rats were administered normal saline water intraperitoneally (ip) while the other experimental groups were given 0.3 mg/kg bodyweight of steroidal solution which was prepared in peanut oil.
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