Role of buspirone in lithium treated rats
2004
Ahmed, S.P. | Rahman, A.B. | Khan, R.A. | Mahay-Rookh (Karachi Univ. (Pakistan). Dept. of Pharmacology) | Haider, S.
Lithium is antimanic and mood stabilizing drugs. It is used for the prevention of mood swings in patients of with bipolar disorder. Lithium probably affects electrolyte and ion transport that modulates neurotransmitter release. Lithium influences second messenger mediating transmitter action, it affects mainly inositol triphosphate and Diacylgycerol system (IP3/DAG). Lithium toxicity occurs at when lithium concentration becomes high. Lithium intoxication can manifest in a number of ways. Lithium may cause serotonin syndrome a state of hyperexcitability. Lithium can increase serotonin metabolite. Buspirone is 5HTIA against and atypical anxiolytic. Busiprone specifically blocks presynaptic 5HT autoreceptors and reduce post synaptic 5HTIA receptor mediated neurotransmission. It also reduces density of 5HT2 receptor. Buspirone is also a weak D2 antagonist. Present work was designed to assure the role of this anxiolytic in hyper activity and hyperexcited condition induced by lithium and the effect on some anxiolytic assessment tests.
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