Antiinflammatory activity of a Ghanaian antiarthritic herbal preparation: III.
1995
Kweifio-Okai, G. | Bird, D. | Field, B. | Ambrose, R. | Carroll A. R. | Smith, P. | Valdes, R.
alpha-Amyrin palmitate, present in a Ghanaian antiarthritic herbal preparation of Alstonia boonei, Elaies [Elaeis] guineensis and Rauvolfia vomitoria, was synthesised from alpha-amyrin acetate isolated from A. boonei root bark, and tested against complete Freund's adjuvant-induced arthritis in rats. Administered orally at 56 mg/kg daily for 8 days, from days 11 to 18 after inoculation of the hindfoot with the adjuvant (acute), or at 66 mg/kg every 48 h for 5 days, from days 32 to 40 (chronic), the drug altered the increases in serum hyaluronate and blood granulocytes towards non-arthritic levels and corrected the moderate anaemia of adjuvant-induced arthritis. Histological examinations of the proximal interphalangeal foot joints showed reduced synovial proliferation and invasion of joints, and reduced leucocyte infiltration of bone marrow and periarticular tissue in treated rats. The results suggest that alpha-amyrin palmitate contributes to the previously shown antiarthritic effect of the herbal preparation.
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