Effects of alpha, alpha-dialkyl amino acids on the protease resistance of peptides
2003
Yamaguchi, H. (Saga Univ. (Japan)) | Kodama, H. | Osada, S. | Kato, F. | Jelokhani-Niaraki, M. | Kondo, M.
A tryptic [EC 3.4.21.4] digestion assay of 2-aminoisobutyric acid (Aib)-containing peptides was carried out to investigate the effect of a,a-dialkyl amino acid residues on the protease resistance. The introduction of Aib residues to the P1' positions exhibited a 19-fold higher protease resistance than the peptide with Aib residues introduced to the P2 position or the non-Aib peptide. The peptide having Aib residues introduced to the P1' and P2 positions resulted in complete resistance.
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