Regulatory Effects of Exercise and Dietary Intervention in Mitogen Activated Protein Kinase Signaling Pathways in Rats
2004
Lee, J.S. (Korean National Sport University, Seoul, Republic of Korea) | Kwon, Y.W. (Korean National Sport University, Seoul, Republic of Korea) | Lee, J.K. (Korean National Sport University, Seoul, Republic of Korea) | Park, J.B. (Korean National Sport University, Seoul, Republic of Korea) | Kim, C.H. (Korean National Sport University, Seoul, Republic of Korea) | Kim, H.S. (Korean National Sport University, Seoul, Republic of Korea) | Kim, C.K. (Korean National Sport University, Seoul, Republic of Korea)
As a central component of a novel protein kinase cascade, the activation of the mitogen-activated protein (MAP) kinase cascade has attracted considerable attention. We sought to determine the effect of exercise and diet on the activation of the extracellular-signal regulated protein kinase (ERK) 1/2 and the p38 MAP kinase pathways in rat soleus muscle. Forty-eight Sprague-Dawley rats were assigned to one of two dietary conditions: high-carbohydrate (CHO) or high-fat (FAT). Animals having each dietary condition were further divided into one of three subgroups: a sedentary control group that did not exercise (NT), a group that performed 8 weeks of treadmill running and was sacrificed 48 h after their final treadmill run (CE), and a group that was sacrificed immediately after their final routine exercise training (AE).
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