Evaluation of the developmental toxicity of aldicarb in the rat
2005
Farag, A.T.,Alexandria Univ. (Egypt). Dept. of Pesticide Chemistry andToxicology
Aldicarb, 2-methyl-2-(methylthio)-propionaldehyde O-methylcarbamoyloxime, iscurrently manufactured in the US by Rhone- Poulenc Company and sold under thetrade name Temik. In the present study, aldicarb was evaluated for potentialdevelopmental toxicity. Groups of 30 bred females Fischer 344 rats were given 0, 0.1,0.3 and 0.5 mg/kg per day by gavage on gestation days 6-15; the fetuses wereevaluated on gestational day 21. Clinical signs of toxicity attributed to aldicarb werenoted in dams receiving 0.3 and 0.5 mg/kg per day. Maternal and fetal brainacetylcholinesterase activities were reduced in treated groups of 0.3 and 0.5 mg/kgper day. Maternal effects in the treated group of 0.5 mg/kg per day includeddepressed body weight. Fetal weight and viability were decreased and fetal death,early and late resorption were increased at the 0.5 mg/kg per day maternal dose.Skeletal abnormalities were also increased in this group. Aldicarb showed fetotoxiceffects at a maternal dose of 0.5 mg/kg per day, a dose that also produced maternaltoxicity.
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