The effect of neem (Azadirachta indica) aqueous extract anddietary selenium on distribution of selenium in liver tissue duringhepatocarcinogenesis
2004
Hanachi, P.,University Putra Malaysia, Serdang (Malaysia). Dept.of Biomedical Sciences
This study aimed to determine the distribution of selenium in theliver of rats during hepatocarcinogenesis when neem aqueous extractand dietary selenium was supplemented. The selenium distribution ofthe 9 diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF)induced hepatocarcinogenesis in Sprague dawley male rats as well asthe other 9 normal rats, which were supplemented with 5% (w/v)neem leaves aqueous extract, 1.85 mg L-1 sodium selenate and tapwater ad libitum according to the treatment groups for 10 weeks,were assessed with energy filter transmission electron microscope(EFTEM) by electron spectroscopic imaging (ESI)-3 window power lawmethod. The result showed that the selenium distribution mean scorein normal control group was the lowest and cancerous control groupwas the highest. However, the selenium distribution mean score innormal supplemented with 5% (w/v) neem leaves aqueous extractincreased about 26% (p less than 0.05) compared to normal controlgroup. This study suggested that neem leaves aqueous extract maybe a potential primary chemopreventive agent rather than assecondary chemopreventive agent.
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