Modulation of immunoglobulin A (IgA) response by oligofructose and its synergistic sets with Bifidobacteria in rats
Biedrzycka, E. | Bielecka, M. | Wroblewska, B. | Jedrychowski, L. | Zdunczyk, Z.(Polish Academy of Sciences, Olsztyn (Poland). Inst. of Animal Reproduction and Food Research)
The previous study on rats showed that orally administered bifidobacteria stimulated the specific anti-Salmonella Enteritidis immunoglobulin A response (SE IgA R) in blood serum. The aim of the present study was to examine whether prebiotics and synbiotics could modulate SE IgA R as well. During a 2-week experiment, oligofructose as prebiotic (5 percent in feed; OF group), and the synergistic sets of OF and Bifidobacterium strains, including B. longum, B. longum, and B. animalis, as synbiotics , were administered to rats. Half the animals in each group were challenged orally with S. Enteritidis 458 as bacterial antigen. SE IgA R was determined by direct immunometric ELISA method. The results indicate that prebiotics and probiotics managed pathogenic activity in GI tract using different mechanisms - oligofructose possibly as a receptor analogue for pathogenic bacteria, and bifidobacteria by their immune-stimulating activity. Therefore, the SE IgA R obtained was not the effect of synergistic action of synbiotic components
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