Therapy of acute T-2 toxin poisoning
2005
Jacevic, V.
The aim of this study was to investigate the effects of soluble and depot forms of methylprednisolone and their combination on 24-hour survival, general health, body weight gain, food and water consumption and pathohistological alterations in heart of rats acutely poisoned with 1 LD50 of T-2 toxin (0.23 mg/kg sc). Eighty female Wister rats 4-6 weeks old, weighing 200-250 g, were used in these experiments. T-2 toxin that was used in these experiments was produced in laboratory conditions from Fusarium sporotrichoides fungi, cultivated on synthetic GPY (glucose 5%, peptone 0.1%, yeast extract 0.1%, pH 5.4) medium. The results obtained confirmed that single administration of 1 LD50 of T-2 toxin produced a significant decreased of body weight gain, food and water consumption and caused damage of the whole heart structure. In rats acutely poisoned with T-2 toxin, a total number and intensity of haemorrhages was higher, distribution of glycogen granules was changed, a total number of mast cells was higher, and the degree of their degranulation was in correlation with the degree of heart structural lesions. Based on the results obtained it is clear that T-2 toxin is one of the most important and strongest mycotoxins that induces extremely harmful changes in the organism of human and animals. Single administration of methylprednisolone significant decreased the toxic effects of T-2 toxin. Methylprednisolone induced decreases the gross pathohistological alterations in heart of T-2 toxin poisoned rats and support the assumption that glucocorticoids have a complex role in protection of animals against T-2 toxin.
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