Anti-fungal activities of constituents from Uvaria scheffleri and Artabotrys brachypetalus
2006
Odebode, A.C. (University of Dar es Salaam, Dar es Salaam (Tanzania). Department of Botany) | Jonker, S.A. (University of Dar es Salaam, Dar es Salaam (Tanzania). Department of Chemistry) | Joseph, C.C. (University of Dar es Salaam, Dar es Salaam (Tanzania). Department of Chemistry) | Wachira, S.W. (University of Dar es Salaam, Dar es Salaam (Tanzania). Department of Chemistry)
The anti-fungal activity of schefflone, a mixture of dimmer, 3,5 dimethoxy carvacrol and annonaceous acetogenin, extracted from stem-bark and root of Uvaria scheffleri and Artabotrys brachypetalus against Fusarium solani, Botryodiplodia theobromae, Aspergillus niger and Aspergillus flavus was determined. An in-vitro bioassay showed that the minimum inhibitory effect of the compounds to the fungal pathogens occurred at 200 ppm in both radial growth and mycelia dry weight measurements. Acetogenin from A. brachypetalus had a very strong anti-fungal effect on all the test fungi. The effects of the compounds were more pronounced on F. solani than on the other. The bioassay methods also play a significant role in the sensitivity of the samples on the pathogens.
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