Lyme borreliosis: insights into tick-/host-borrelia relations. A review
Grubhoffer, L.(Akademie Ved, Ceske Budejovice (Czech Republic). Parazitologicky Ustav)E-mail:liborex@paru.cas.cz | Golovchenko, M.(Akademie Ved, Ceske Budejovice (Czech Republic). Parazitologicky Ustav) | Vancova, M.(Akademie Ved, Ceske Budejovice (Czech Republic). Parazitologicky Ustav) | Zacharovova-Slavickova, K.(Akademie Ved, Ceske Budejovice (Czech Republic). Parazitologicky Ustav) | Rudenko, N.(Akademie Ved, Ceske Budejovice (Czech Republic). Parazitologicky Ustav) | Oliver, J.H.(Georgia Southern Univ., Statesboro (USA). Inst. of Arthropodology and Parasitology)
Lyme borreliosis (LB) is a serious infectious disease of humans and some domestic animals in temperate regions of the Northern Hemisphere. It is caused by certain spirochetes in the Borrelia burgdorferi sensu lato (s.l.) species complex. The complex consists of 11 species. Borrelia burgdorferi sensu stricto, Borrelia garinii and Borrelia afzelii are the major agents of human disease. Borrelia burgdorferi s.l. species are transmitted mainly by ticks belonging to the Ixodes ricinus species complex. B. burgdorferi infections may produce an acute or chronic disease with a wide array of clinical symptoms. An overview of the knowledge of molecular factors with emphasis on potential protein-carbohydrate interactions in the tick-borrelia system is presented.
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