Fatal actinobacillosis in a dairy buffalo
2006
Muhammad, G.(University of Agriculture, Faisalabad (Pakistan). Dept. of Veterinary Clinical Medicine and Surgery) | Saqib, M.(University of Agriculture, Faisalabad (Pakistan). Dept. of Veterinary Clinical Medicine and Surgery) E-mail:[email protected] | Athar, M.(University of Agriculture, Faisalabad (Pakistan). Dept. of Veterinary Clinical Medicine and Surgery)
An 8-year old Nili-Ravi buffalo cow in the 4th month of her 5th lactation was presented for the treatment of actinobacillosis. Clinical signs included a large multilobular, firm abscess located caudo-ventral to the right ear base, submandiblar and prescapular lymphadenopathy, fever and dyspnoea. Haemogram revealed an accelerated erythrocyte sedimentation rate and erythropenia. Provisional diagnosis of actinobacillosis was confirmed by the demonstration of a Gram-negative pleomorphic organism in pus, microscopic examination of a compression preparation of a sulphur granule as well as growth of the organism on blood agar. Intraperitoneal inoculation of pus in guinea pigs was fatal at around 48 hours post-injection. The LD50 of the Actinobacillus lignieresii isolate in mice was 104 colony forming unit/mL of Hank's balanced salt solution. The animal died 12 hours after the initiation of surgical drainage of the abscess and administration of iodide, antibiotics and steroids. Necropsy findings included interlobular pneumonia, pulmonary abscessation and mediastinal lymphadenopathy.
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