Pharmacological studies on carthamin, red pigment and saflor yellow, yellow pigment from Carthamus tinctorius
2003
Kasahara, Y. (Yamagata-ken. Inst. of Public Health (Japan))
The crude drug "Kouka" prepared from the flower petals of Carthamus tinctorius, has been used for the treatment of women's diseases in Japanese and Chinese medicine. We have recently examined the pharmacological properties of C. tinctorius, and found that it has an analgesic effect, inhibitory effect of spontaneous motor activity, sedative effect and antiinflammatory effect. In the present work, we investigated the preventive action of red and yellow pigments, carthamin and saflor yellow respectevely, from C.tinctorius on acute inflammations. A C.tinctorius extract inhibited the hind-paw edema induced by carrageenin and histamine. Carthamin and saflor yellow suppressed the acetic acid-induced writhing, prolonged the hexobarbital-induced hypnosis period and inhibited the carrageenin and histamine-induced hind paw edema in mice.
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