An evaluation of evolutionary theories based on genomic structures in Saccharomyces cerevisiae and Encephalitozoon cuniculi
2004
Sorimachi, K. (Dokkyo Univ., Mibu, Tochigi (Japan). School of Medicine) | Okayasu, T.
Codon usage patterns in 16 chromosomes coincided with each other in Saccharomyces cerevisiae, and the same result was obtained from Encephalitozoon cuniculi consisting of 11 chromosomes, although each chromosome function differs. In addition, preferential codon usage in the regenerated coding systems for Leu and Lys differed between Saccharomvces cerevisiae and Encephalirozoon curncull. These results cannot be explained by Darwin's natural selection theory or by the neutral theory proposed against Darwin's. Furthermore, the codon usage patterns were examined in both prokaryotes and eukaryotes. The use of G or C at the third codon position was much lower than T or A in Ureaplasma urealyticum, whereas inversely the use of G or C at the third codon position was much higher than T or A in Mycobacterium tuberculosis. Additionally. Candida aibicans and Plasmodium falciparum also showed a very low usage of G or C at the third codon position. It is a difficult leap to speculate that the inverse codon usage change occurred over the genome during biological evolution. Thus, the present resuits strongly suggest that organisms were derived from different origins, indicating that the origin of life was plural. based on genomic structures.
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