Effects of Ethylacetate Fraction of Plantain (Plantago asiatica L.) on Experimentally-Induced Gastric Mucosal Damage and Gastric Ulcers in Rats
Won, Y.J.;Na, M.S.;Lee, M.Y.(Chosun University, Gwangju, Republic of Korea)E-mail:[email protected]
Plantain has been used for antidiarrhea, antihemorrhage and the remedy of indigestion. Plantain was extracted with ethanol and fractionated systemically with n-hexane, chloroform, ethylacetate (EtOAC) and n-butanol. Antioxidant index (AI was expressed as induction period of oil containing various fractions/induction period of oil of 600 ppm) of EtOAC fraction was the highest among fractions in vitro. The protective effects of the EtOAC fraction of plantain (PE) administered 1 mL orally or intraduodenally on experimentally induced gastritis, gastric ulcer and gastric secretion were evaluated in rats. Sprague-Dawley rats weighing 250∼300 g were divided into 4 groupsnegative control group (CON), PE 200 ㎎/㎏ treated group (PEL), PE 400 ㎎/㎏ treated group (PEH) and positive control group (cimetidine 100 ㎎/㎏-CMT or omeprazol 100 ㎎/㎏ treated group-OMT), respectively.
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