Preparation and biological evaluation of ∨99mTc tricarbonyl cysteine
Jang, B.S.;Yun, H.I.(Chungnam National University, Daejeon, Republic of Korea)E-mail:hiyun@cnu.ac.kr | Park, K.B.(Korea Atomic Energy Research Institute, Daejeon, Republic of Korea)
This paper describes the development of ∨99mTc tricarbonyl cysteine as potential renal function diagnostic radiopharmaceutical and evaluation of its biological characteristics using experimental animals. ℓ-Cysteine was labeled efficiently with ∨99mTc tricarbonyl precursor ([∨99mTc(CO)₃(H₂O)₃)]+) under 30 min heating at 75℃. Labeling yield and stability were analyzed by high performance liquid chromatography (HPLC). The biodistribution property of ∨99mTc tricarbonyl cysteine in mice and its dynamic imaging profiles in rabbits were carried out.
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