A potential role of Schwann cells in spinal nerve roots in autoimmune central nervous system diseases
Moon, C.J.;Lee, Y.D.;Shin, T.K.(Cheju National University, Jeju, Republic of Korea)E-mail:shint@cheju.ac.kr
The expression of nestin and vimentin in the spinal nerve roots of rats with experimental autoimmune encephalomyelitis (EAE) was studied to ascertain whether Schwann cells in the peripheral nerves respond to acute central nervous system autoimmune injury. Immunohistochemistry demonstrated that nestin was constitutively expressed in the dorsal roots of spinal nerves in control ratsits expression was enhanced in the spinal nerve roots of rats with EAE. Vimentin expression was weak in control rat spinal nerve roots, and it was increased in the dorsal roots of rats with EAE.
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