Evaluation of maternal toxicity in rats exposed to the insecticide amitraz during pregnancy
Shin, J.Y.;Oh, K.S.;Shin, D.H.;Kim, S.H.;Kim, J.C.(Chonnam National University, Gwangju, Republic of Korea) | Kim, H.C.(Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea) | Park, S.C.(Kyungpook National University, Daegu, Republic of Korea) | Lee, H.S.;Chung, M.K.(Korea Institute of Toxicology, KRICT, Daejeon, Republic of Korea)
The present study was carried out to investigate the potential adverse effects of amitraz on pregnant dams after maternal exposure during the gestational days (GD) 1 through 19 in Sprague-Dawley rats. The test chemical was administered orally to pregnant rats at dose levels of 0, 3, 10, or 30 mg/kg/day. During the test period, clinical signs, mortality, body weights, food consumption, serum biochemistry, gross findings, organ weights and reproductive findings on GD 20 were examined. In the 30 mg/kg group, an increase in the incidence of abnormal clinical signs and death, a suppression in the body weight gain, and a decrease in the food consumption were observed.
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