Canine biphasic synovial sarcoma: case report and immunohistochemical characterization
Panayiotis Loukopoulos(National Cancer Center Research Institute, Tokyo, Japan)E-mail:ploukopo@gan2.res.ncc.go.jp | Hock Gan Heng(Universiti Putra Malaysia, Selangor Darul Ehsan, Malaysia) | Habibah Arshad(Royal Veterinary College, North Mymms, Hatfield, United Kingdom)
The clinical, radiological and pathologic features of a biphasic synovial sarcoma in the left elbow joint of a two-year-old male Rottweiler are presented. The tumor showed positive immunoreactivity for vimentin, Epithelial Membrane Antigen (EMA), p53 and PCNA, while it was negative for the cytokeratin used, S-100, Rb and p21. Immunohistochemistry for EMA allowed the identification of epithelioid components of synovial sarcoma, and may, therefore, contribute in establishing a diagnosis of biphasic synovial sarcoma.
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