General pharmacological profiles of bee venom and its water soluble fractions in rodent models
Kim, H.W.;Ham, T.W.;Roh, D.H.;Yoon, S.Y.;Kang, S.Y.;Yang, I.S.;Lee, J.H.(Seoul National University, Seoul, Republic of Korea)E-mail:[email protected] | Kwon, Y.B.(Chonbuk National University, Jeonju, Republic of Korea) | Han, H.J.(Chonnam National University, Gwangju, Republic of Korea) | Lee, H.J.(Kyung Hee University, Seoul, Republic of Korea) | Alvin J. Beitz(University of Minnesota, St Paul, MN, USA)
Recently, the antinociceptive and anti-inflammatory efficacy of bee venom (BV, Apis mellifera) has been confirmed in rodent models of inflammation and arthritis. Interestingly, the antinociceptive and anti-inflammatory effect of whole BV can be reproduced by two water-soluble fractions of BV (greater than 20 kDa:BVAF1 and less than 10 kDa: BVAF3). Based on these scientific findings, BV and its effective water-soluble fractions have been proposed as potential anti-inflammatory and antinociceptive pharmaceuticals.
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