Anti-Inflammatory Activities of a Herbal Preparation GCSB-5 on Acute and Chronic Inflammation
2005
Kim, S.H. (Sungkyunkwan University, Suwon, Republic of Korea) | Lee, C.H. (Sungkyunkwan University, Suwon, Republic of Korea) | Lee, J.S. (Sungkyunkwan University, Suwon, Republic of Korea) | Cho, K.H. (Sungkyunkwan University, Suwon, Republic of Korea) | Kim, S.O. (Biosapogen Co., Ltd., Seongnam, Republic of Korea) | Cho, S.H. (Hanpoong Pharmaceutical Co., Ltd., Jeonju, Republic of Korea) | Cho, H.K. (Hanpoong Pharmaceutical Co., Ltd., Jeonju, Republic of Korea) | Lee, S.M. (Sungkyunkwan University, Suwon, Republic of Korea), E-mail: [email protected]
GCSB-5 is a purified extract from a mixture of 6 Oriental herbs (Ledebouriellae Radix, Achyranthis Radix, Acanthopanacis Cortex, Cibotii Rhizoma, Glycine Semen, and Eucommiae Cortex) that have been widely used for the treatment of inflammatory diseases in the East Asia. The aim of this study was to investigate the anti-inflammatory potential of GCSB-5. The animals used in this study were administered either vehicle or GCSB-5 (30, 100, 300, and 600 mg/kg) orally. The GCSB-5 significantly inhibited the increase of acetic acid-induced vascular permeability (30.9-34.2% inhibition at 30-300 mg/kg).
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