Study on the Reproductive and Developmental Toxicity of 3-MCPD
2004
Kwack, S.J. (National Institute of Toxicological Research, KFDA, Seoul, Republic of Korea) | Chung, Y.H. (Occupational Safety and Health Research Institute, Daejeon, Republic of Korea) | Kim, S.S. (National Institute of Toxicological Research, KFDA, Seoul, Republic of Korea) | Choi, Y.W. (National Institute of Toxicological Research, KFDA, Seoul, Republic of Korea) | Rhee, G.S. (National Institute of Toxicological Research, KFDA, Seoul, Republic of Korea) | Sohn, K.H. (National Institute of Toxicological Research, KFDA, Seoul, Republic of Korea) | Lee, R.D. (National Institute of Toxicological Research, KFDA, Seoul, Republic of Korea) | Chae, S.Y. (National Institute of Toxicological Research, KFDA, Seoul, Republic of Korea) | Park, K.L. (National Institute of Toxicological Research, KFDA, Seoul, Republic of Korea), E-mail: [email protected] | Yu, I.J. (Occupational Safety and Health Research Institute, Daejeon, Republic of Korea)
3-Monochloro-1,2-propanediol(3-MCPD) is a toxic compound, often present in different foods containing acid hydrolyzed(AH) protein, like seasonings and savory food products. The purpose of the present study was to investigate the effects of 3-MCPD on male fertility, sperm and testosterone secretion. In vivo male fertility test was performed for observing the adverse effects of 3-MCPD on the function of male reproductive system and pregnancy outcome. 0.01, 0.05, 0.25, 1 and 5 mg/kg b.w. of 3-MCPD was given daily by gavage to groups of 15 adult male SD rats for 4 weeks. At the end of pre-treatment period, males were mated overnight with normal females.
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