Evaluation of Maternal Toxicity in Mice Exposed to the Environmental Pollutant 2-Bromopropane during Pregnancy
2004
Heo, J.D. (Korea Institute of Toxicology, KRICT, Daejeon, Republic of Korea), E-mail: [email protected] | Kim, M.K. (Chungnam National University, Daejeon, Republic of Korea) | Kim, J.C. (Chonnam National University, Gwangju, Republic of Korea) | Kim, C.Y. (Korea Institute of Toxicology, KRICT, Daejeon, Republic of Korea) | Ziang, Chen Zhe (Korea Institute of Toxicology, KRICT, Daejeon, Republic of Korea) | Suh, J.E. (Korea Institute of Toxicology, KRICT, Daejeon, Republic of Korea) | Chung, M.K. (Korea Institute of Toxicology, KRICT, Daejeon, Republic of Korea) | Shin, D.H. (Chungnam National University, Daejeon, Republic of Korea)
2-Bromopropane (2-BP), a halogenated propane analogue, is a substitute for chlorofluorocarbones (CFCs). The present study was carried out to investigate the potential adverse effects of 2-BP on pregnant dams after maternal exposure during the gestational days (GD) 6 through 17 in ICR mice. The test chemical was administered subcutaneously to pregnant mice at dose levels of 0, 500, 1000, and 1500 mg/kg/day. All pregnant females were subjected to autopsy on GD 18.
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