Acute Oral Toxicity Study of Standardized Gami-Honghwa-Tang (KH-19) in Rats and Beagle Dogs
2005
Yu, Y.B. (Korea Institute of Oriental Medicine, Daejeon, Republic of Korea), E-mail: [email protected] | Sung, H.J. (Halla Oriental Hospital, Seoul, Republic of Korea) | Yoon, Y.S. (Korea Institute of Oriental Medicine, Daejeon, Republic of Korea)
Gami-Honghwa-Tang (KH-19), a herbal prescription for reducing the side effect of radiotherapy, is composed of eight crude herbs such as Rehmanniae Radix Preparata, Angelicae Gigantis Radix, Cnidii Rhizoma, Paeoniae Radix, Corni Fructus, Moutan Cortex Radicis, Lycii Fructus, Carthami Flos, and Glycyrrhizae Radix. In this study, marker substances in KH-19 were analyzed by high performance liquid chromatography-diode array detector (HPLC-DAD) and safety evaluation of standardized KH-19 was evaluated by good laboratory practices (GLP) guideline of Korea Food and Drug Administration.
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