Primary dermal irritation study of oregano oil in rabbits
2005
Shin, J.Y. (Chonnam National University, Gwangju, Republic of Korea) | Park, S.C. (Kyungpook National University, Daegu, Republic of Korea) | Kim, K.H. (Biomist Co., Daejeon, Republic of Korea) | Bae, J.H. (Korea Institute of Toxicology, KRICT, Daejeon, Republic of Korea) | Shin, D.H. (Chonnam National University, Gwangju, Republic of Korea) | Kim, S.H. (Chonnam National University, Gwangju, Republic of Korea) | Bae, C.S. (Chonnam National University, Gwangju, Republic of Korea) | Kim, J.C. (Chonnam National University, Gwangju, Republic of Korea), E-mail: toxkim@chonnam.ac.kr
The present study was carried out to investigate the skin irritation potential of oregano oil in rabbits. A volume of 0.5 ml of test article was applied to intact and abraded skins, respectively, for 24 h in 6 healthy male New Zealand White rabbits. Parameters measured during 72 h observation period were mortality, clinical signs, body weight changes, and local irritation. Treatment-related toxic symptoms, as evidenced by anorexia and decreased locomotor activity, were observed in all rabbits tested. Two rabbits out of the 6 total died on day 2 after the application of test article due to treatment-related toxicity.
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