Solution Structure of Human Atrial Natriuretic Peptides (7-28)
2005
Lee, Y.K. (Konkuk University, Seoul, Republic of Korea) | Lim, Y.H. (Konkuk University, Seoul, Republic of Korea), E-mail: [email protected]
The natriuretic peptides consist of three families, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). CNP is observed in the central and peripheral tissues, functioning as an autocrine or paracrine regulator, whereas ANP and BNP are produced by the atrium and ventricle and function as cardiac hormones. ANP was first isolated from human atrial extracts, and BNP and CNP from porcine brain. Natriuretic peptides have a ring structure by a disulfide bond. Seventeen residues, which show a high sequence homology, are included in the ring structure. Therefore, exocyclic N-terminal and C-terminal residues make differences in natriuretic peptides, which cause different binding affinities for natriuretic peptide receptors.
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