Efficacy of carboplatin and radiation on malignant histiocytosis in a Bernese mountain dog
2006
Echigo, R.(Tokyo Univ. (Japan)) | ; Andoh, M. | ; Nakayama, H. | ; Nishimura, R. | ; Matsunaga, S. | ; Sasaki, N.
A 6-year-old Bernese mountain dog was presented with a large subcutaneous mass diagnosed as malignant histiocytosis on the left forelimb. Although the mass and the regional lymph node were surgically resected, the mass recurred in 3 days. Then the orthovoltage radiation (total 36 Gy) and chemotherapy with carboplatin (300 mg/ square m, 9 times) were conducted over 6 months after the surgery. In 6 months, the mass was completely disappeared without any recurrence and metastasis. However, after the complete remission for over 450 days, the tumor recurrence was observed on 684 days after the first admission, and the left forelimb was amputated due to pathologic fracture. At 850 days after the first admission, pulmonary metastasis was observed, and the owner did not want further treatments. Although this malignant neoplasia is difficult to cure, adjunctive carboplatin administration and radiation may be one of the effective treatments for malignant histiocytosis in Bernese mountain dogs.
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