Staphylococcus aureus Siderophore-Mediated Iron-Acquisition System Plays a Dominant and Essential Role in the Utilization of Transferrin-Bound Iron
2005
Park, R.Y. (Chosun University, Gwangju, Republic of Korea) | Sun, H.Y. (Chosun University, Gwangju, Republic of Korea) | Choi, M.H. (Chosun University, Gwangju, Republic of Korea) | Bai, Y.H. (Chosun University, Gwangju, Republic of Korea) | Shin, S.H. (Chosun University, Gwangju, Republic of Korea), E-mail: [email protected]
Staphylococcus aureus is known to be capable of utilizing transferrin-bound iron, via both siderophoreand transferrin-binding protein (named IsdA)-mediated iron-acquisition systems. This study was designed in order to determine which iron-acquisition system plays the essential or dominant role with respect to the acquisition of iron from human transfenin, in the growth of S. aureus. Holotransferrin (HT) and partially iron-saturated transferrin (PT), but not apotransferrin (AT), were found to stimulate the growth of S. aureus. S. aureus consumed most of the transferrin-bound iron during the exponential growth phase.
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