Protective Effect of Pterocarpus santalinus on Galactosamine Induced Liver Damage
2006
Dhanabal, S.P. (Department of Pharmacognosy and Pharmacology, JSS College of Pharmacy, Rocklands,OOtacamund), E-mail: [email protected] | Syamala, G. (PSG College of Pharmacy, Coimbatore, Tamilnadu, India) | Elango, K. (Department of Pharmacognosy and Pharmacology, JSS College of Pharmacy, Rocklands,OOtacamund) | Suresh, B. (Department of Pharmacognosy and Pharmacology, JSS College of Pharmacy, Rocklands,OOtacamund)
The present study was carried out to investigate the hepatoprotective effect of the extract of Pterocarpus santalinus Linn on acute hepatotoxicity induced in Wistar albino rats by a single dose of Galactosamine (400 mg/kg). Suspensions of methanolic extract of heartwood of P. santalinus (200 and 400 mg/kg) in 0.3% Carboxy Methyl Cellulose (CMC) were administered p.o. to experimental animals and hepatoprotective activity was monitored by estimating aspartate amino transferase (ASAT, GOT), alanine amino transferase (ALAT, GPT), alkaline phosphatase (ALP), total bilirubin (TB), lactate dehydrogenase (LDH), total cholesterol (TC), triglycerides (TGL), albumin, total protein (TP) levels.
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