Antiulcer Activity of Sida acuta Burm
2006
Malairajan, p. (C.L.Baid Metha College of Pharmacy, Thoraipakkam, Tamilnadu India), E-mail: [email protected] | Gopalakrishnan, Geetha (R n D Leader, Schering Plough Link, Singapore Ranch, Tuas West Drive) | Narasimhan, S. (Director, Asthagiri Herbal Research foundation, Tambaram Sanatorium, India) | Veni, K.J.K. (S.R.M. College of Pharmacy, Kattankulathur, Kancheepuram India)
The ethanol extract of Sida acuta Burm. (ALSA) whole plant was studied for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer, HCl-ethanol induced ulcer, and water immersion stress induced ulcer (WISIU) in rats. We found that ALSA at a dose of 300 mg/kg, (orally) markedly decrease the incidence of ulcers in the first two models. ALSA showed reduction in gastric volume, free acidity, and ulcer index (53.69%). It has not reduced the total acidity significantly and no significant change in pH.
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