Anthelmintic efficacy of extracts of Spigelia anthelmia Linn on experimental Nippostrongylus braziliensis in rats
2006
Jegede, Olorunfemi Cornelius (Ahmadu Bello University, Zaria, Nigeria), E-mail: [email protected] | Ajanusi, Joseph Ologunja (Ahmadu Bello University, Zaria, Nigeria) | Adaudi, Ambrose. O. (Ahmadu Bello University, Zaria, Nigeria) | Agbede, Rowland I.S. (Ahmadu Bello University, Zaria, Nigeria)
Spigelia anthelmia Linn is used as a herb and is a common annual weed of cultivation in open re-growths, on unused land in towns as well as on road sides. The plant can grow to approximately 30 cm in height. The aim of this study was to screen extracts of Spigelia anthelmia for their anthelmintic activity against an experimental Nippostrongylus braziliensis infection in rats. Acute oral toxicity occurred at a dose of 1,140 mg/kg, while anthelmintic trials against Nippostrongylus braziliensis in rats using the aqueous fraction showed a progressive decrease in worm count with increasing dose (10, 13, 16, 20 and 25 mg per kg body weight) (p less than 0.05).
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