Postruminal delivery system for amino acids and proteins in cattle
2007
Sykora, T.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Ustav Farmakologie | Rabiskova, M.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Ustav Farmakologie | Trinacty, J.,Agrovyzkum, Rapotin (Czech Republic) | Vetchy, D.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Ustav Farmakologie | Haering, A.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Ustav Farmakologie | Dvorak, P.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Ustav Biochemie, Chemie a Biofyziky
The purpose of this experiment was to develop an effective postruminal transport system (PTS) with a high content of suitable vegetable proteins and amino acids. PTS serves for nutrient delivery to the abomasum and small intestine of dairy cows in order to increase the milk yield. PTS consists of a core (pellets, small tablets) and a coating, which protects the core against the environment of rumen and enables to release the core content in the environment of abomasum and small intestine. Lenticular tablets - cores of PTS were prepared by wet granulation method and compression. Qualitative indicators of tablets (average weight, weight uniformity, hardness, friability, disintegration time) were determined according to valid Czech and European Pharmacopoeias. Cores were subsequently coated with several types of coating - ethylcellulose, stearic acid and pH sensitive polymer poly-(2-vinylpyridine-co-styren), alone or in combination of various rates. Nine samples of coated protein tablets exhibiting appropriate characteristics in vitro were prepared. The presence of the pH sensitive polymer at least in 10% concentration of the coating and the coating amount of 9.0 to 12.6% per tablet were necessary to ensure the requested PTS properties.
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