Development Of Hairless Laboratory Guinea Pigs : The Biological Studies
2007
Todehdehghan, F., Motedayen | Gholami, M.R., Members of Scientific Board of Razi Institute. Keraaj, Iran
Hairless guinea pigs of Razi colony is produced from colored strain . At times of birth they are smaller than their litter mate and have loss and thin hair , specially at the muzzle portion where hair loss starts at age of 8-10 days old and last till 20-30 days when animal becomes hairrless . They only mate with normal haired guinea pigs and their litter size is 1-4. Life spane is approximately 2 years. They have normal thymus (euthymic) and gonads. Hairaless guinea pigs with brown - white color have smooth and fine skin without wrinkles while in black - brown strain they have thick and wrinkled skin. Hairless guina pig´s skin differ from normal animal by the absence of normal hair follicles and keratine.Number of rythrocytes, PCV , platelets and hemoglobin values are higher in hairless guinea pigs than in haired one. Leukocytes in both group have not shown significant difference. Number of lymphocytes in hairless are lower than haired animal. Glucose , total protein, albumin , globulin and bilirubin values have not shown differences in both group. In this study we have determined the nuclei of hairless guinea pig by animal mating selection , and the hairless animal with normal thymus (euthymic) andappropriate life spane was produced under conventional conditions. These animals are first hairless models in Iran which could be used in study of allergy , dermal tests, transplantation, immunology and dermal diseases.
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