Chemopreventive effects of minor dietary constituents in common foods on human cancer cells
2007
Cherng, J.M.(China Medical Univ., Taichung (Taiwan)) | Shieh, D.E. | Chiang, W. | Chang, M.Y. | Chiang, L.C.
Epidemiological evidence has sugged that vegetables and fruits may have a role in cancer prevention. The aim of the present study was to examine the anti-proliferative activity of ten related pure compounds from common vegetables and fruits. Studies were conducted on a series of carcinoma cells derived from eight human organs. The results show that linalool possessed the strongest activity against nine carcinoma cells, and that baicalein and luteolin also exhibited a broad spectrum of anti-proliferative activities. Among them, linalool showed the strongest activity against carcinoma of the cervix (ICsub(50): 0.37 microg/ml), stomach (ICsub(50): 14.1 microg/ml), skin(ICsub(50): 14.9 microg/ml), lung(ICsub(50): 21.5 microg/ml) and bone (ICsub(50): 21.7 microg/ml). As for the flavonoids, luteolin exhibited the strongest activity against carcinoma of the stomach (ICsub(50): 7.1 microg/ml), cervix (ICsub(50): 7.7 microg/ml), lung (ICsub(50): 11.7 microg/ml) and bladder(ICsub(50): 19.5 microg/ml), whereas baicalein possessed the strongest anti-proliferative activity against carcinoma of the cervix(ICsub(50) : 9.8 microg/ml), stomach(ICsub(50): 16.1 microg/ml) and skin(ICsub(50): 19.5 microg/ml). The present study indicates that linalool possessed the strongest activity against a broad spectrum of carcinoma cells, especially cervical carcinoma cells, suggesting that linalool and flavonoids are partially responsible for the cancer prevention of common vegetables and fruits.
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